Zonulin is the fecal protein that best reflects the intestinal permeability. Its increased fecal levels are considered to be a marker of an impaired intestinal barrier, and reflect reactions secondary to inflammation. Elevated calprotectin levels in our IBD cohort reflect an inflammatory state.
According to the manufacturer, a median concentration of 61 ng/mL (± 46 ng/mL) fecal zonulin was estimated as 'normal' for healthy persons. For serum zonulin, a median value of 34 ng/mL (± 14 ng/mL) was declared as normal for healthy persons.