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Active-B12, Holotranscobalamin (holoTC)
What it measures
Vitamins
Clinical significance
Holotranscobalamin represents only 10-30% of the Vitamin B12 circulating in the blood but is the ONLY form of Vitamin B12 that is taken up and used by cells of the body, hence it's other name ACTIVE -B12. An active B12 test measures the amount of B12 that available for your body to use. Vitamin B12 is important for red blood cell formation and a healthy nervous system. B12 deficiency can cause almost any psychiatric symptom, from anxiety, and panic to depression and hallucinations. This is because B12 deficiencies trigger symptoms in the nervous system and red blood cells.
The normal range for holoTC is 23–100 pmol/L. Low holoTC is an early indicator of low B-12.
Emerging evidence indicates that a low level of Active B12 is a more reliable marker of impaired vitamin B12 status than a low level of serum vitamin B12. Moreover unlike serum B12, Active B12 is believed to be stable in pregnancy.
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